Dren is the main antagonist of the 2009 Canadian-French horror film Splice.

Although they are forbidden from doing so, a scientist couple introduces human DNA into their animal hybridization experiments, creating a hybrid creature they name "Dren".


In her infant form, Dren is a two-legged creature with pale skin, minimal facial features, a theropod-like stance, and digitigrade legs. As she grows, she learns to stand more erect and gains a more human-like face, as well as a long prehensile tail and feet resembling high heeled shoes. Eventually, she transitions from female to male.

Powers and Abilities

Dren possesses the following powers and abilities:

  • Accelerated growth
  • Human intelligence
  • Amphibious locomotion
  • Sharp teeth
  • Retractable wings
  • Venomous stinger


Dren is murdered by Elsa, but Elsa is later revealed to be pregnant with the recently-male Dren's child.


  • Dren's name is "nerd" backward, referring to the scientists' employer, N.E.R.D..

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